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1. Clinical study Adam, M. [1991]: Which effect have Gelatine preparations? Therapy of Osteoarthritis. Therapiewoche 41; 38: 2456-2461
• Goal: Effect of Collagen-Hydrolysate of the osteoarthritis pain
• Randomised, double blind Cross-Over-Study
• Patients collective: 52 evaluated patients with degenerative joint diseases of the knee or hip joints
• Studies time period: 16 Month
• Result: significant pain diminution
Download Study (Sorry, but this is only in German Language available)
2. Clinical studies Moskowitz, R.W.: Role of Collagen Hydrolysate in Bone and Joint Disease. Seminars in Arthritis and Rheumatism, Vol. 30, No 2; 87-99
• Goal: Evaluation of the effectiveness of daily 10 g collagen hydrolysate on the pain diminution at gon arthrosis in comparison with placebo
• Randomised, double blind, placebo-controlled Multi-Centre-Study
• Patients collective: 389 Patients with a diagnosed gon arthrosis (knee joint osteoarthritis)
• Studies time period: 1996-1998 in the USA, Great Britain, Germany
• Treatment time period: 24 Weeks with a then 8-week Wash-out-Phase
• Result: Assessment of the therapy success with the WOMAC scale, a special pain score scale which takes into account pains and joint function at arthrosis
• Goal: Proof about the absorption, distribution and enrichment of 14C-marked collagen hydrolysate in comparison with 14C-marked proline
• In Vivo-Study: Animal
• Studies time period: 192 h
• Result: Collagen hydrolysate is absorbed provably in the intestines and accumulates in comparison with other fabrics preferentially in the joint cartilage.
Collagen Safety:
In a review on the role of collagen hydrolysate by Professor Roland Moskowitz, M.D. in bone and joint disease, he commented on the excellent safety profile of collagen hydrolysates. He also noted that partially hydrolyzed collagen has been used as a food since at least early medieval times. Various collagen hydrolysate products have been affirmed as GRAS (generally regarded as safe) by the FDA. He also notes that Collagen hydrolysate is of interest as a therapeutic agent of potential utility in the treatment of osteoarthritis and osteoporosis. Its high level of safety makes it attractive as an agent for long-term use in these chronic disorders.