1. Clinical study Adam, M. [1991]: Which effect have Gelatine preparations? Therapy of Osteoarthritis. Therapiewoche 41; 38: 2456-2461

Goal: Effect of Collagen-Hydrolysate of the osteoarthritis pain
Randomised, double blind Cross-Over-Study
Patients collective: 52 evaluated patients with degenerative joint diseases of the knee or hip joints
Studies time period: 16 Month
Result: significant pain diminution

 



2. Clinical studies Moskowitz, R.W.: Role of Collagen Hydrolysate in Bone and Joint Disease. Seminars in Arthritis and Rheumatism, Vol. 30, No 2; 87-99

Goal: Evaluation of the effectiveness of daily 10 g collagen hydrolysate on the pain diminution at gon arthrosis in comparison with placebo
Randomised, double blind, placebo-controlled Multi-Centre-Study
Patients collective: 389 Patients with a diagnosed gon arthrosis (knee joint osteoarthritis)
Studies time period: 1996-1998 in the USA, Great Britain, Germany
Treatment time period: 24 Weeks with a then 8-week Wash-out-Phase
Result: Assessment of the therapy success with the WOMAC scale, a special pain score scale which takes into account pains and joint function at arthrosis




3. Cell - Study Oesser et al. [1999]: Oral Administration of 14C Labeled Gelatin Hydrolysate Leads to an Accumulation of Radioactivity in Cartilage of Mice. J. Nutr. 129: 1891-1895

Goal: Proof about the absorption, distribution and enrichment of 14C-marked collagen hydrolysate in comparison with 14C-marked proline
In Vivo-Study: Animal
Studies time period: 192 h
Result: Collagen hydrolysate is absorbed provably in the intestines and accumulates in comparison with other fabrics preferentially in the joint cartilage.




4. Cell - Study Oesser et al. [2003]: Stimulation of Type II collagen bisynthesis and secretion in bovine chondrocytes with degraded collagen. Cell Tissue Res 311: 393-399

• Influence of collagen hydrolysate (3.3 kD) on the type II collagen biosynthesis in bovine Chondrozyten in comparison with control substances
In-Vitro-Cell culture model
Studies time period: 11 Weeks
Result: After conclusion of the examination row an approximately 2.5 times higher type II collagen synthesis could be proved in comparison with control into the Chondrozyten treated with collagen hydrolysate Þ very significant increase of the type II collagen new entity


 
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